Read the article commenting on Arthur Beaudet’s recent publication featuring Prof Thierry online: Circulating Fetal Cells Sequenced for Prenatal Testing Study
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Marnie Winter and Benjamin Thierry from the University of South Australia, together with Tina Bianco-Miotto, Claire Roberts, and Clare Whitehead of the University of Adelaide in Australia and the University of Toronto in Canada, will develop and test short-interfering RNAs (siRNA) high-density lipoprotein (HDL) nanocarriers for the treatment of preeclampsia. Globally, ten million women develop preeclampsia during pregnancy each year, which results in the deaths of 76,000 women and 500,000 babies; 99% of these are in developing countries. Most current treatments focus on treating the symptoms (high blood pressure and proteinuria) rather than the molecular causes. Some of the causative molecules, such as the angiogenesis inhibitor sFlt1, can be blocked by specific siRNAs, but the challenge is targeting the siRNAs to the right cells in the body. HDL delivery systems for this purpose are effective and safe, and both siRNAs and HDLs are stable at room temperature, important for therapies in resource-poor areas. They will optimize the formulation of their HDL nanocarrier manufacturing platform, and characterize siRNA loading, carrier stability, size, cellular uptake, and silencing ability in 2D culture. Further, they will bioengineer an ex-vivo placenta model that fully recapitulates the structural and phenotypic complexity of a preeclamptic placenta and use it to evaluate tissue penetration and silencing abilities of the siRNA-nanocarrier complex.
Congratulation to the team for bringing Ferronova’s technology to this point. Read the comment in the Lead here.
Congratulation to Duy for the publication of his manuscript “Silicon Nanowires Field Effect Transistors: A Comparative Sensing Performance between Electrical Impedance and Potentiometric Measurement Paradigms” in Analytical Chemistry.
Congratulation to Ludivine for the publication of her manuscript “A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models ” in Biomaterials.
Congratulations to Valentina, Thuy and Meysam for submitting their PhD theses in July 2019 – and all the best for their future endeavors at UniSA or elsewhere.
Congratulation to Marnie for being awarded a South Australia Tall Poppy award!
More info on the AIPS web page.
Congratulation to Thuy and Duy for featuring on the front page of the Herald Sun! Duy’s presentation of our point of care testing platform for preeclampsia attracted significant interest. Look out for the publication reporting this exciting work and other further exciting development.
Read the press release here.
Congratulation to Marnie and all the team on being awarded a grant from the Trasher Foundation.
On behalf of the chairs of the symposium Dr Chih-Tsung Yang and Dr Michelle Maritz and myself, I thank all the speakers of the inaugural ‘International Symposium: Bioengineered Cancer Models’. What a great turn out for what ended being a very exciting event with fascinating presentations illustrating the potential of bioengineered models in immunotherapy and radiotherapy.
‘International Symposium: Bioengineered Cancer Models’
|9:30 – 10:00||Guest arrival and coffee
|10:00 – 10:15
Chair: Professor Peter Hoffmann
Acknowledgement of Country and Introduction of SA Chief Scientist: Professor Peter Hoffmann (University of South Australia)
Opening note: Professor Caroline McMillen (SA Chief Scientist)
Introduction of French – South Australia collaboration: Ms Patricia Thomasi (A/Director, Office of the French Strategy, Department of the Premier and Cabinet)
|10:15 – 12:00
Chair: Professor Benjamin Thierry
10:15: Adapting a 3D Microfluidic Culture System to Study Immune Checkpoint Blockade for Personalized Immunotherapy Developing a Functional Precision Medicine Platform for Immuno-Oncology Dr Amir Aref (Dana Farber Cancer Research Institute, Harvard University)
10:50: Professor Wayne Tilley (University of Adelaide)
11:25: A new versatile microfluidic system to simulate human physiology in a chip Dr Pierre Gaudriault (Cherry Biotech)
|12:00 – 13:00||Lunch|
|13:00 – 14:45
Chair: Dr Chih-Tsung Yang
13:00: 3D vascularised microfluidic systems to study the role of tumour stromal cells in immunotherapy of triple negative breast cancer A/Professor Majid Ebrahimi Warkiani (University of Technology Sydney)
13:35: 3D bioprinting of high-throughput (HTP) tumour spheroids for precision medicine Dr Lakmali Atapattu (University of New South Wales)
14:10: Development of a novel solid tumour CAR-T therapy Dr Justin Coombs (Carina Biotech)
|15:05 – 16:30
Chair: A/Professor Ivan Kempson
15:05: Proton Therapy – Coming Soon to Australia Associate Professor Hien Le (Radiation Oncology, Royal Adelaide Hospital)
15:15: Radiation biology and the quest for personalized cancer therapies: in vitro and in silico approaches Professor Eva Bezak (University of South Australia)
15:50: Towards bioengineered head and neck cancer models Dr Michelle Maritz (University of South Australia)
16:15: Quantitative Imaging and Machine Learning in Translational Research Dr Jonathan Cechetto (PerkinElmer)
Chair: Professor Benjamin Thierry
|Selected flash presentation session
16:30: Decoding the endosomal trafficking system through live-cell microscopy Dr. Senthil Arumugam (University of New South Wales)
16:35: Pre-clinical assessment of Chimeric Antigen Receptor (CAR)T cells using patient derived xenograft (PDX) mouse models Dr. Alla Dolnikov (Kids Cancer Centre, Sydney Children’s Hospital)
16:40: A humanised bone marrow xenotransplantation model of Acute Myeloid Leukaemia to predict patient outcome and direct therapy Dr Thao M. Nguyen (University of South Australia)
16:45: Drop-on-demand 3D bioprinting of 3D cell models Dr Robert Utama (Inventia Life Science)