Archive for Uncategorized

Congratulations to Valentina, Thuy and Meysam for submitting their PhD theses

Congratulations to Valentina, Thuy and Meysam for submitting their PhD theses in July 2019 – and all the best for their future endeavors at UniSA or elsewhere.

Marnie awarded a 2019 SA Tall Poppy

Congratulation to Marnie for being awarded a South Australia Tall Poppy award!

More info on the AIPS web page.

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Preeclampsia testing FET technology on the front page of the Herald Sun

Congratulation to Thuy and Duy for featuring on the front page of the Herald Sun! Duy’s presentation of our point of care testing platform for preeclampsia attracted significant interest. Look out for the publication reporting this exciting work and other further exciting development.

Read the press release here.

Congratulation to Marnie for being awarded a Trasher ECR grant

Congratulation to Marnie and all the team on being awarded a grant from the Trasher Foundation. Trasher

‘International Symposium: Bioengineered Cancer Models’

On behalf of the chairs of the symposium Dr Chih-Tsung Yang and Dr Michelle Maritz and myself, I thank all the speakers of the inaugural ‘International Symposium: Bioengineered Cancer Models’. What a great turn out for what ended being a very exciting event with fascinating presentations illustrating the potential of bioengineered models in immunotherapy and radiotherapy.

 

‘International Symposium: Bioengineered Cancer Models’

9:30 – 10:00 Guest arrival and coffee
10:00 – 10:15

 

Chair: Professor Peter Hoffmann

Opening session

Acknowledgement of Country and Introduction of SA Chief Scientist: Professor Peter Hoffmann (University of South Australia)

Opening note: Professor Caroline McMillen (SA Chief Scientist)

Introduction of French – South Australia collaboration: Ms Patricia Thomasi (A/Director, Office of the French Strategy, Department of the Premier and Cabinet)

10:15 – 12:00

 

Chair: Professor Benjamin Thierry

Session 1

10:15: Adapting a 3D Microfluidic Culture System to Study Immune Checkpoint Blockade for Personalized Immunotherapy Developing a Functional Precision Medicine Platform for Immuno-Oncology Dr Amir Aref (Dana Farber Cancer Research Institute, Harvard University)

10:50: Professor Wayne Tilley (University of Adelaide)

11:25: A new versatile microfluidic system to simulate human physiology in a chip Dr Pierre Gaudriault (Cherry Biotech)

12:00 – 13:00 Lunch
13:00 – 14:45

 

Chair: Dr Chih-Tsung Yang

Session 2

13:00: 3D vascularised microfluidic systems to study the role of tumour stromal cells in immunotherapy of triple negative breast cancer A/Professor Majid Ebrahimi Warkiani (University of Technology Sydney)

13:35: 3D bioprinting of high-throughput (HTP) tumour spheroids for precision medicine Dr Lakmali Atapattu (University of New South Wales)

14:10: Development of a novel solid tumour CAR-T therapy Dr Justin Coombs (Carina Biotech)

15:05 – 16:30

 

 

Chair: A/Professor Ivan Kempson

 

 

 

Session 3

15:05: Proton Therapy – Coming Soon to Australia Associate Professor Hien Le (Radiation Oncology, Royal Adelaide Hospital)

15:15: Radiation biology and the quest for personalized cancer therapies: in vitro and in silico approaches Professor Eva Bezak (University of South Australia)

15:50: Towards bioengineered head and neck cancer models Dr Michelle Maritz (University of South Australia)

16:15: Quantitative Imaging and Machine Learning in Translational Research Dr Jonathan Cechetto (PerkinElmer)

16:30 -16:50

 

 

 

Chair: Professor Benjamin Thierry

Selected flash presentation session

16:30: Decoding the endosomal trafficking system through live-cell microscopy Dr. Senthil Arumugam (University of New South Wales)

16:35: Pre-clinical assessment of Chimeric Antigen Receptor (CAR)T cells using patient derived xenograft (PDX) mouse models Dr. Alla Dolnikov (Kids Cancer Centre, Sydney Children’s Hospital)

16:40: A humanised bone marrow xenotransplantation model of Acute Myeloid Leukaemia to predict patient outcome and direct therapy Dr Thao M. Nguyen (University of South Australia)

16:45: Drop-on-demand 3D bioprinting of 3D cell models Dr Robert Utama (Inventia Life Science)

Congratulation to Marnie for being awarded a Partnership Grant

Congrats to Marnie and all the team for being awarded a 2019 Partnership Enabling Grant Scheme (PEGS) from the University of South Australia. The project will bring together the expertise of the group in isolating rare circulating fetal cells with that of Professor Jiuyong Li (Professor of Computer Science at the School of Information Technology and Mathematical Science of the University of South Australia) and Dr Thuc  Le (Bioinformatics, University of South Australia).

The project is entitled “A novel approach to better understand preeclampsia molecular disease aetiology” and will develop new methodologies and achieve proof-of-principle for transcriptomic analysis of circulating fetal cells.

 

7th MolecularDx Europe – 6th – 9th May Lisbon

Only a few days before the 7th MolecularDx Europe and what an exciting conference this will be.

See our invited talk reporting NIPDx technology to isolate circulating fetal trophoblastic cells in the “Enabling Technologies for Circulating Biomarkers” symposium.

About Molecular Diagnostics Europe


Cambridge Healthtech Institute’s Seventh International Molecular Diagnostics Europe event will move to a larger venue for 2019 – the Lisbon Marriott Hotel – from 6-9 May. This meeting provides a nexus for diagnostic developers in academia and industry as well as end users in the pharmaceutical and healthcare sector to gain a comprehensive picture of molecular diagnostics in the prenatal, oncology, infectious disease, point-of-care, and liquid biopsy fields, plus new coverage of biomarkers for immunotherapy and companion diagnostics for immuno-oncology. This exciting area has attracted attendance of over 400 delegates to learn what novel technologies, platforms and applications are emerging that will impact future healthcare delivery and pharmaceutical research. Join us this spring at this expanding event at the epicenter of diagnostics.

Welcome to the International Symposium Bioengineered Cancer Model – June 21

The bioengineering group is organizing this exciting event to be chaired by Prof Benjamin Thierry and Dr Chih-Tsung Yang. Please join us. Symposium BioEngineered Models

Joint publication in Vietnam Journal of Chemistry

Congratulation to the team at the Microfabrication Laboratory and Pilot Plant Center for the publication of the article “Possible detection of antibiotic residue using molecularly imprinted polyaniline-based sensor” in the Vietnam Journal of Chemistry.

Congratulation to Tyron for his paper in ACS Nano

Congrats to Tyron and Ivan for the acceptance of the manuscript “Cross-Correlative Single-Cell Analysis Reveals Biological Mechanisms of Nanoparticle Radiosensitization” in ACS Nano. The article is online here.

Abstract

Nanoparticle radiosensitization has been well demonstrated to enhance effects of radiotherapy, motivated to improve therapeutic ratios and decrease morbidity in cancer treatment. A significant challenge exists in optimizing formulations and translation due to insufficient knowledge of the associated mechanisms which have historically been limited to physical concepts. Here we investigated a concept for the role of biological mechanisms. The mere presence of gold nanoparticles lead to a down regulation of thymidylate synthase, important for DNA damage repair in the radioresistant S phase cells. By developing a cross-correlative methodology to reveal probabilistic gold nanoparticle uptake by cell sub-populations and the associated sensitization as a function of the uptake, a number of revealing observations have been achieved. Surprisingly, for low numbers of nanoparticles a desensitization action was observed. Sensitization was discovered to preferentially impact S phase cells where impairment of the DNA damage response by the homologous recombination pathway dominates. This small but radioresistant cell population correlates with much greater proliferative ability. Thus a paradigm is presented whereby enhanced DNA damage is not necessarily due to an increase in the number of DNA Double Strand Breaks (DSBs) created, but can be from a nanoparticle-induced impairment of the damage response by down regulating repair proteins such as thymidylate synthase.